PHOTOS FROM THE ESH-iCMLf 14th INTERNATIONAL CONFERENCE ON CHRONIC MYELOID LEUKEMIA: BIOLOGY AND THERAPY HELD IN BALTIMORE IN SEPTEMBER 2012
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Photos from the ESH International Conference on MDS held in Dublin in April 2012
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Photos from the ESH-EHA Scientific Workshop on MSC held in Mandelieu in April 2012

From April 20-22 2012, the third meeting on mesenchymal stromal cells was held in Mandelieu France. While the first two meetings covered MSC biology in a broader sense, this meeting focused on the anti-inflammatory and immune modulatory properties rather then on the regenerative properties of MSCs. In addition, the scientific committee had a global representation in an attempt to harmonize development in the field in Europe, North America and Japan. The invited speakers included well known scientists from Europe and North America (Canada and USA), as well as from Japan and China. In addition, space was created to allow 21 abstracts to be presented in the form of short oral presentations of 10 minutes each. The meeting hosted a total of 125 participants, who actively participated in the discussions.
The first session focused on the ontogeny and development of MSCs. Topics included the role of MSCs in liver fibrosis and the role of FGF receptors in MSC development. Darwin Prockop from Temple focused on the proteins produced by MSCs and that play a role in modulation of immune responses, focusing in particular on the protein TSG-6. The role of chemokines and soluble mediators in the MSC mediated immune modulation was also discussed and this was connected to a clinical presentation of application of MSCs in autoimmune disorders. Imaging of MSCs in-vivo is becoming one of the major topics to further advance MSC therapy. Novel approaches were discussed to enhance the in-vivo targeting of systemically administered MSCs to the site of inflammation in murine models. It is likely that engineered approaches will become important and may lead to a reduction in the numbers of cells required to achieve a therapeutic effect.
It is well known that interactions between hematopoietic stem cells and MSCs in the bone marrow hematopoietic stem cell niche are of great importance in regulating hematopoiesis. Recent evidence suggests that niche specific signaling may facilitate tumor progression by providing specific signals for the maintenance and survival of tumor cells. Other evidence suggests that a subset of bone marrow stromal cells, the nestin positive MSCs, are targeted by the sympathetic nervous system and are involved in the regulation of hematopoietic trafficking. These and other abstracts were discussed in a session on the normal and malignant stem cell niche.
In the final session a variety of clinical applications of MSCs were presented and discussed. This included the use of MSCs in the treatment cytopenia, autoimmune disorders and graft-versus-host disease as well using MSCs in co-cultures to expand cord blood-derived hematopoietic stem cells. The safety of MSC therapy, including immunogenicity, the possibility for malignant transformation and genetic stability were extensively discussed.
Willem Fibbe Katarina Le Blanc Francesco Dazzi
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Photos from the ESH-EBMT Training Course held in Sofia in April 2012

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Photos from the ESH ENERCA III Conferenceheld in Paris in February 2012

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Photos from the ESH- iCMLf Conference held in Estoril in September 2011

Participants in Estoril appreciated that the CML conference fostered junior researchers and offered the possibility to discuss informally with world-renowned researchers and clinicians. They generally felt that the balance between scientific and clinical sessions was achieved and that the event offered good insight into new concepts in CML. Many particularly enjoyed the size of the event making it easy to speak to fellow scientists and clinicians as well as with faculty members. Oral presentations made by post-doctoral students were also popular; participants enjoyed the “hands-on” focus they gave to the conference.

What they said: “Excellent biological and clinical interface.”; “Post-doc presentations gave an excellent hands-on focus to the meeting.” “The meeting was a great opportunity to meet the world-wide experts in the field of CML.”; “the meeting was exactly the right size.” ; “I was able to get updated on new basic research approaches and enjoyed the quality of speakers, the informal format, the location and the interaction with colleagues!”

The conference was supported in part from educational grants from BMS (Diamond Conference Partner), Pfizer Oncology (Emerald Conference Partner), Ariad (Ruby Conference Partner) and Novartis Oncology (Ruby Conference Partner).

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Photos from the ESH- iCMLf Conference Held in Washington in September 2010

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