ESH Video

World Cord Blood Congress V and Innovative Cell Therapies

Chairperson: E. Gluckman

SESSION I – STEM CELL BIOLOGY

– State of the art – T. Enver
Do we need a different niche for fast haematopoietic reconstitution in cord blood transplantation?
G. Koegler
Emergence of fetal immune-restricted lympho-myeloid progenitors prior to definitive haematopoietic stem cells -S.E. Jacobsen
– Programming haematopoietic stem cells during development -R. Patient
– UM171 expansion of human CB stem cells -G. Sauvageau
Cord blood stem cells acquire the signature of induced pluripotent stem cells (iPS) when transplanted
F. Frassoni

SESSION II – METHODS Of GRAFT FACILITATION I

– State of the art – E.J. Shpall
– Stem Regimen-1 Expanded umbilical cord blood transplantation – J. Wagner
Nicord expands haematopoietic stem cells and shortens time to engraftment in patients undergoing
cord blood transplantation for haematological malignancies and sickle cell disease – J. Kurtzberg
Rescue of the mucocutaneous manifestations in a mouse model of recessive dystrophic epidermolysis bullosa (RDEB) by human cord blood (CB) derived unrestricted somatic stem cells (USSCS) – M. Cairo
History and future of cord blood transplantation – E. Gluckman 

SESSION III – METHODS Of GRAFT FACILITATION II

– Can MSC facilitate engraftment and haematopoietic reconstitution? – F. Dazzi
Single versus double cord blood transplant in children – J. Wagner
– Single versus double cord blood transplant in adults – A. Ruggeri

SESSION IV – EVOLUTION IN CORD BLOOD BANKING

Introduction of the Cord Blood Bank Technology Survey (WMDA-NetCord) – E. Baudoux
Cost efficiency of cord blood banks – S. Querol
– Use of population data to project cord blood registry size – M. Boo
Contribution of Eurocord registry to the improvement of cord blood banking – I. Ionescu

SESSION V – IMMUNOGENETICS OF DONOR CHOICE

– State of the art – E. Petersdorf
– Selecting cord blood units in 2015 – M. Eapen
– The role of NK cell killer immunoglobulin receptor genomics on the outcome of cord blood transplantation – K. Rezvani
– The complexity of the MHC in HLA matching with the use of next generation sequencing technologies – A. Madrigal
Analysis of classical HLA haplotypes can predict outcomes of haematopoietic stem cell transplantation – R. Tamouza
– IRES: an immune reconstitution study of umbilical cord blood transplant recipients – J. Girdlestone
– Impact of CTLA4 genotype and other immune response gene polymorphisms on umbilical cord blood transplantation outcomes – R. Cunha

SESSION VI – ETHICAL AND LEGAL ASPECTS

– So called “MSCs”: concepts and misconceptions, use and misuse, science and empirism – P. Bianco
– Cell-based therapies in Europe: legal requirements and ethical issues – A. Altavilla
– Stem cells from therapy to drug – S. Panis

SESSION VII – CURRENT RESULTS OF CORD BLOOD TRANSPLANTATION 
RESULTS IN CHILDREN

 – Transplantation of cord blood cells as a successful treatment in children with haemoglobinopathies – F. Locatelli
Importance of CD4+ lymphocyte reconstitution following cord blood transplantation – P. Veys
Towards individualized conditioning regimens to improve  the outcomes of cord blood transplantation – J. Boelens
– UCBT for childhood AML : the impact of cytogenetic – G. Michel

RESULTS IN ADULTS: 

– Are the criteria of donor choice in adults different from children ? – V. Rocha
How to improve cord blood transplant results in adults – J. Sanz

SESSION VIII – IMMUNOMODULATION FOR CORD BLOOD TRANSPLANTATION

– Redirecting T cell specificity post transplant – C. June
Prevention of GVHD by umbilical cord blood derived T- regulatory cells – J. Wagner
– Therapeutic immune regulation with mesenchymal stromal cells – W. Fibbe
– Engineering intrinsic resistance to HIV infection – C. June

SESSION IX – COMPARISON WITH OTHER SOURCES OF STEM CELLS

– T cell-replete, HLA-haploidentical stem cell transplantation – E. Fuchs
– Comparison of cord blood and non T depleted related haplo transplant in adults – A. Ruggeri
– Comparison of cord blood transplant to T depleted haplo transplant in children – F. Locatelli
Prospective study on allogeneic transplant in acute myeloid leukaemia according to the policy of the Rome Transplant
network for donor selection: HLA identical sibling vs matched unrelated vs haploidentical related donor – W. Arcese
– Is survival better when patients are enrolled on a clinical trial? – M. Eapen

SESSION X – SELECTED ABSTRACTS FOR ORAL PRESENTATIONS

Assessment of adhesion and homing molecules alteration in ex vivo expansion of umbilical cord blood CD34+ haematopoietic stem cells – M. N. Zarif
Comparison of HLA-G expression in mesenchymal stromal cells derived from bone marrow, placenta, umbilical cord and amniotic membrane – M. N. Zarif
Inventory depuration – L. Ponce-Verdugo
Clinical utility of family-directed cord blood storage – M. Abecasis
– Comparing volume reduction and quality parameters of large volume cord blood units (CBs) – after cryopreservation with HES and non-HES – the Düsseldorf experience
S.Schwandt
Comparison of the results of haemoglobin pattern screened in different public health services: umbilical cord blood bank of the Hospital de Clínicas de Porto Alegre (BSCUP-HCPA) and newborn screening reference service of Rio Grande Do Sul (SRTN-RS), Brazil –  L.M. Röhsig
Substantially reduced red cell contamination with comparative nucleated cell recovery using sample specific red cell depletion and plasma  reduction technique (a retrospective analysis of 9637 umbilical cord blood units at LifeCell International, India) – P. Dhot
Umbilical cord blood collection: first year operations at the Canadian Blood Services, National Public Cord Blood Bank – H. Elmoazzen

SESSION XI – in association with Monacord and Centre Scientifique de Monaco :
DEVELOPMENT OF STEM CELL TRANSPLANT IN EMERGING COUNTRIES: THE EXAMPLE OF SICKLE CELL ANAEMIA

– Establishing a haematopoietic stem cells transplant program in sub-Saharan Africa – D. Diallo
– Access to safe and effective transfusion clinical program – S. Diop
Treatment of sickle cell disease in emerging countries – M. de Montalembert
Indication of bone marrow transplantation in sickle cell disease – F. Bernaudin
– Bone marrow transplant for sickle cell disease in Brazil – B. Simoes
International survey of haematopoietic stem cell transplant from an HLA identical sibling for sickle cell disease – B. Cappelli
Establishing a cost-effective national cord blood registry in a resource restricted environment- S. Narayan
A potential treatment for beta-thalassemia and sickle cell disease via high-efficiency targeted genome editing of hematopoietic stem cells – M.Walters

SESSION XII – NEW INNOVATIVE THERAPY TO TREAT NON-MALIGNANT DISEASES

Gene therapy for hereditary disorders – J.A Ribeil
– Update on haematopoietic and mesenchymal cell therapy for the treatment of autoimmunes diseases – D. Farge
– Immunopsychiatry: from pathways to innovative therapies – M. Leboyer & R. Tamouza
Indications and results of the use of stem cells for regenerative medicine – G. Koegler
– The potential of cord blood to treat genetic and acquired brain diseases – J. Kurtzberg