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ESH-EHA Scientific Workshop: LEUKEMIC AND CANCER STEM CELLS

ESH-EHA Scientific Workshop: LEUKEMIC AND CANCER STEM CELLS
April 03 - April 05, 2009 - Mandelieu, France
Chairs :

Information

In May, the ESH Workshop on leukaemic and cancer stem cells was held in the south of France and welcomed over 160 participants. It was chaired by Dominique Bonnet, Christine Chomienne and Peter Valent.

Feedback from the participants was very positive; they particularly enjoyed the sessions on targeting leukaemic stem cells and stem cell pathways. ESH plans to run this workshop again in two-year’s time.

Programme

Friday, April 3, 2009
Session 1 Signatures of «stem cellness»
Part I Chairperson: Dominique Bonnet
14h30 - 15h00 Transcription factor C/ EBP alpha regulates hematopoietic stem cell proliferation during aging D. Tenen (Boston)
15h00 - 15h30 Towards the goal of suppressing leukemic stem cell function K. Humphries (Vancouver)
15h30 - 16h00 JunB limits hematopoietic stem cell functions as a protective mechanism against initiation of myeloid malignancy E. Passegué (San Francisco)
16h00 - 16h30 Coffee break and poster viewing
Part II Chairperson: Hervé Chneiweiss
16h30 - 17h00 Epigenetic therapy and re-programming of cancer self-renewing cells S. Baylin (Baltimore)
17h00 - 17hh30 ROS, DNA damage and repair in Leukemic stem cells F. Rassool (Baltimore)
17h30 - 18h00 Neoplastic stem cells in leukemias: a critical review of methodologies and results P. Valent (Vienna)
18h00 - 18:30 Identification of regulatory networks specific for acute myeloid leukemia stem cells K. Eppert (Toronto)
18h30 - 18:45 Both leukemia and normal stem cells can be discriminated in BM samples in AML G. Schuurhuis (Amsterdam)
18h45 - 20h00 Welcome coktail and manned poster session
20h00 Dinner
Saturday, April 4, 2009
Session 2 Malignant stem cells in hematopoietic disease: identification and targeting
Part I Chairperson: Philippe Rousselot
09h00 - 09h30 Novel targets for eradication of cancer stem cells in CML T. Holyoake (Glasgow)
09h30 - 10h00 Targeting the survival and engraftment of CML stem cells R. Van Etten (Boston)
10h00 - 10h15 Targeting the leukemic stem cell in mouse models of myeloid (pre) leukemia R.A. Padua (Paris)
10h15-10h30 Idiopathic myelofibrosis generated by transplantation of STAT5A (1*6) transduced hematopoietic stem cells to irradiated mice S. Takafumi (Tokyo)
10h30-10h45 Dysregulation of pi 3kinase in MDS stem cells S. Corey (Chicago)
10h45 - 11h00 Coffee break and poster viewing
Part II Chairperson: Jean Christopne Bories
11h00 - 11h30 Myeloma stem cells R. Jones (Baltimore)
11h30 - 12h00 Stem cells in childhood ALL T. Enver (Oxford)
12h00 - 12h15 LIC are frequent in very high risk childhood percursor B ALL M. Schmitz (Zurich)
12h15 - 12h30 Identification of putative stem cells in CLL M. Shehata (Vienna)
12h30 - 14h00 Lunch and poster viewing
Session 3 Workgroups
Chairpersons G. de Haan, J.J. Schuringa, D. Bonnet, F. Pflumio, H. Chneiweiss, T. Jaffredo, S. Robine
14h00-16h00 Workgroups
- Workgroup on cell culture, amplification and banking
- Workgroup on animal models and engraftment
- Workgroup on immuno-staining, cell sorting and purification
16h00-16h30 Coffe break and poster viewing
16h30 - 18h00 Plenary Session: Highlights on cancer stem cell assays & summary of the workgroups
Chairpersons D. Charron, H. Chneiweiss, T. Jaffredo, F. Pflumio, S. Robine
18h00 Manned poster session and drinks
20h00 Dinner
Sunday, April 5, 2009
Session 4 Cancer Stem cell markers and assays
Part I Chairperson: Michèle Goodhardt
08h45 - 09h15 Exploiting genetic variation to uncover transcriptional networks in hematopoiesis G. de Haan (Groningen)
09h15 - 09h45 BMI1 collaborates with BCR-ABL in inducing leukemic transformation of human CD34+cells in vitro and in vivo J.J. Schuringa (Groningen)
09h45 - 10h15 Utility and pitfall of the xenotransplantation model in the study of leukemic stem cells D. Bonnet (London)
10h15 - 10h45 Coffee break and poster viewing
Part II Chairperson: Rose-Ann Padua
10h45 - 11h00 Rapid and efficient differentiation of leukemic cells into immunostimulatory dendritic cells: a possible reservoir of LSC antigens M. Cassuci (Milan)
11h00 - 11h30 Hematopoietic stem cell niches and leukemia stem cells L. Linheng (Kansas)
11h30 - 12h30 Delineating the cellular pathways and the molecular determinants of normal and malignant hematopoiesis S. E. Jacobsen (Oxford)
12h30

Future Stem Cell Networks

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