Immune thrombocytopenia (ITP) is a bleeding disorder characterized by the induction of an autoreactive immune response against one’s own platelets, resulting in increased platelet destruction and reduced megakaryocyte function. In the last 10 years, many publications have shed new light on several clinical and scientific questions relating to ITP. It is now clear that ITP may have more than one etiology and is a complex and heterogeneous disorder and new clinical definitions of the disease have arisen. Perhaps more striking is the rapid evolution of novel therapeutics that have shown great benefit to even the most refractory of patients with ITP and these have been incorporated into new consensus guidelines. This meeting will bring together many of the world’s leading clinical and scientific experts on ITP and will present a comprehensive program of lectures and posters to summarize the current state-of the-art knowledge and treatments of ITP.
Friday, April 30, 2010 |
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Morning: | Basic Science of ITP - Chair: J. Semple | |
09h00 - 09h45 | Megakaryocyte differentiation and platelet production | A. Weyrich (Salt Lake City) |
09h45 - 10h30 | Autoimmune mechanisms and T regulatory cell disturbances in ITP | K. Yazdanbakhsh (New York) |
10h30 - 11h00 | Coffee break | |
11h00 - 11h45 | Mouse models of ITP | J.W. Semple (Toronto) |
11h45 - 12h30 | Peptide therapy for patients with ITP | S. Urbaniak (Aberdeen) |
12h30 - 14h00 | Lunch | |
Afternoon: | Clinical Dilemmas - Chair: D. Provan | |
14h00 - 14h45 |
Pathogenesis of ITP |
D. Cines (Philadelphia) |
14h45 - 15h30 | A patient journey | C. Black (London) |
15h30 - 16h00 | Coffee break | |
16h00 - 16h45 | How useful is the indium labelled platelet survival study? | A. Sarpatwari (London) |
16h45 - 17h30 | Splenectomy – best option for induction of durable remission in chronic ITP? | H. Wadenvik (Gothenburg) |
19h30 | Welcome cocktail | |
20h00 | Dinner | |
Saturday, May 1, 2010 |
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Morning: |
Novel Therapeutics - Chair: D. Kuter |
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09h00 - 09h45 | Thrombopoietin mimetics - old and new |
D. Kuter (Boston) |
09h45 - 10h30 | Clinical studies with TPO mimetics | J. Bussel (New York) |
10h30 - 11h00 | Coffee break | |
11h00 - 11h45 | Anti-CD20 monoclonal antibodies – old and new | M. Michel (Créteil) |
11h45 - 12h30 | Recent advances in Fc receptor-dependant therapies | A. Lazarus (Toronto) |
12h30 - 14h00 | Lunch | |
Afternoon: | Free Communications - Chair: A. Newland | |
5 short communications: 10 minute-presentation followed by a 5 minute-discussion |
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Sunday, May 2, 2010 |
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Morning: | The Future - Chair: D. Cines | |
09h00 - 09h45 | FC Receptors | R. Clynes (New York) |
09h45 - 10h30 | Regulatory antibodies to apoptotic cell membranes: Prospects for treatment of autoimmune diseases |
G. Silverman (La Jolla) |
10h30 - 11h00 | Coffee break | |
11h00 - 11h45 | CTL-mediated ITP |
B. Olsson (Gothenburg) |
11h45 - 12h30 | Future Therapies | A. Newland (London) |
12h30 | Light lunch and departure |