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In May, the ESH Workshop on leukaemic and cancer stem cells was held in the south of France and welcomed over 160 participants. It was chaired by Dominique Bonnet, Christine Chomienne and Peter Valent.
Feedback from the participants was very positive; they particularly enjoyed the sessions on targeting leukaemic stem cells and stem cell pathways. ESH plans to run this workshop again in two-year’s time.
| Friday, April 3, 2009 | ||
| Session 1 | Signatures of «stem cellness» | |
| Part I | Chairperson: Dominique Bonnet | |
| 14h30 - 15h00 | Transcription factor C/ EBP alpha regulates hematopoietic stem cell proliferation during aging | D. Tenen (Boston) |
| 15h00 - 15h30 | Towards the goal of suppressing leukemic stem cell function | K. Humphries (Vancouver) |
| 15h30 - 16h00 | JunB limits hematopoietic stem cell functions as a protective mechanism against initiation of myeloid malignancy | E. Passegué (San Francisco) |
| 16h00 - 16h30 | Coffee break and poster viewing | |
| Part II | Chairperson: Hervé Chneiweiss | |
| 16h30 - 17h00 | Epigenetic therapy and re-programming of cancer self-renewing cells | S. Baylin (Baltimore) |
| 17h00 - 17hh30 | ROS, DNA damage and repair in Leukemic stem cells | F. Rassool (Baltimore) |
| 17h30 - 18h00 | Neoplastic stem cells in leukemias: a critical review of methodologies and results | P. Valent (Vienna) |
| 18h00 - 18:30 | Identification of regulatory networks specific for acute myeloid leukemia stem cells | K. Eppert (Toronto) |
| 18h30 - 18:45 | Both leukemia and normal stem cells can be discriminated in BM samples in AML | G. Schuurhuis (Amsterdam) |
| 18h45 - 20h00 | Welcome coktail and manned poster session | |
| 20h00 | Dinner | |
| Saturday, April 4, 2009 | ||
| Session 2 | Malignant stem cells in hematopoietic disease: identification and targeting | |
| Part I | Chairperson: Philippe Rousselot | |
| 09h00 - 09h30 | Novel targets for eradication of cancer stem cells in CML | T. Holyoake (Glasgow) |
| 09h30 - 10h00 | Targeting the survival and engraftment of CML stem cells | R. Van Etten (Boston) |
| 10h00 - 10h15 | Targeting the leukemic stem cell in mouse models of myeloid (pre) leukemia | R.A. Padua (Paris) |
| 10h15-10h30 | Idiopathic myelofibrosis generated by transplantation of STAT5A (1*6) transduced hematopoietic stem cells to irradiated mice | S. Takafumi (Tokyo) |
| 10h30-10h45 | Dysregulation of pi 3kinase in MDS stem cells | S. Corey (Chicago) |
| 10h45 - 11h00 | Coffee break and poster viewing | |
| Part II | Chairperson: Jean Christopne Bories | |
| 11h00 - 11h30 | Myeloma stem cells | R. Jones (Baltimore) |
| 11h30 - 12h00 | Stem cells in childhood ALL | T. Enver (Oxford) |
| 12h00 - 12h15 | LIC are frequent in very high risk childhood percursor B ALL | M. Schmitz (Zurich) |
| 12h15 - 12h30 | Identification of putative stem cells in CLL | M. Shehata (Vienna) |
| 12h30 - 14h00 | Lunch and poster viewing | |
| Session 3 | Workgroups | |
| Chairpersons | G. de Haan, J.J. Schuringa, D. Bonnet, F. Pflumio, H. Chneiweiss, T. Jaffredo, S. Robine | |
| 14h00-16h00 | Workgroups | |
| - Workgroup on cell culture, amplification and banking | ||
| - Workgroup on animal models and engraftment | ||
| - Workgroup on immuno-staining, cell sorting and purification | ||
| 16h00-16h30 | Coffe break and poster viewing | |
| 16h30 - 18h00 | Plenary Session: Highlights on cancer stem cell assays & summary of the workgroups | |
| Chairpersons | D. Charron, H. Chneiweiss, T. Jaffredo, F. Pflumio, S. Robine | |
| 18h00 | Manned poster session and drinks | |
| 20h00 | Dinner | |
| Sunday, April 5, 2009 | ||
| Session 4 | Cancer Stem cell markers and assays | |
| Part I | Chairperson: Michèle Goodhardt | |
| 08h45 - 09h15 | Exploiting genetic variation to uncover transcriptional networks in hematopoiesis | G. de Haan (Groningen) |
| 09h15 - 09h45 | BMI1 collaborates with BCR-ABL in inducing leukemic transformation of human CD34+cells in vitro and in vivo | J.J. Schuringa (Groningen) |
| 09h45 - 10h15 | Utility and pitfall of the xenotransplantation model in the study of leukemic stem cells | D. Bonnet (London) |
| 10h15 - 10h45 | Coffee break and poster viewing | |
| Part II | Chairperson: Rose-Ann Padua | |
| 10h45 - 11h00 | Rapid and efficient differentiation of leukemic cells into immunostimulatory dendritic cells: a possible reservoir of LSC antigens | M. Cassuci (Milan) |
| 11h00 - 11h30 | Hematopoietic stem cell niches and leukemia stem cells | L. Linheng (Kansas) |
| 11h30 - 12h30 | Delineating the cellular pathways and the molecular determinants of normal and malignant hematopoiesis | S. E. Jacobsen (Oxford) |
| 12h30 |
Future Stem Cell Networks Conference Closure |
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