Training Course on WHO Classification:
Towards Personalized Medicine in Haematology
Chairs: Matteo G. Della Porta, Torsten Haferlach, Andreas Hochhaus,
Eva Hellström-Lindberg, Mario Cazzola
Dates: March 9-11, 2017
Venue: Saggart (Dublin), Ireland
The WHO classification of tumours of haematopoietic and lymphoid tissues aims to establish a pathological and genetic classification of haematological malignancies that is accepted and used worldwide, as a basis for diagnostic work-up, clinical decision making process and clinical trials.
In recent years, the availability of new technologies for genomic analysis (next-generation sequencing, NGS) has enabled the high-throughput screening of somatic mutations in haematological malignancies. It is expected that the results of these studies will significantly improve the management of individual patients through the implementation of innovative diagnostic/prognostic systems and the development of therapeutic strategies based on individual genomic profile.
As a result of recent advances in the understanding of the molecular architecture of haematological malignancies, the 2016 update of the WHO classification includes an increasing amount of new, clinically relevant genomic information and will represent a solid basis for the implementation of personalized (precision) medicine programmes.
In the definition of personalized (precision) medicine, the word personalized conveys the sense that cancer genomic data may facilitate diagnosis and rational treatment choices that are tailored to individual patients, while the term precision refers to prospects for enhanced molecular resolution, mechanistic clarity, and therapeutic cogency that may accompany clinical implementation of genomics technologies.
Conceptually, the implementation of personalized medicine in haematology might seem straightforward: first, characterize the genomes of patients’ tumours using NGS technologies; second, filter the genomic data through a knowledge base of existing and emerging anticancer drugs; and finaly, present an annotated list to haematologists that can be incorporated into clinical decision making.
However, multiple challenges must be addressed to bring this ambitious goal to fruition. To begin with, high-quality genomic information must be obtained consistently in the diagnostic setting. The spread of massive genotyping methods will soon make it possible for clinicians to detect a broad range of mutations in peripheral blood at a reasonable cost. This will facilitate the diagnosis/treatment choice in patients with haematological malignancies. The analytic challenges that accompany comprehensive genomic data have proven more problematic: the somatic alterations that are relevant to each cancer (driver mutations) must be identified with high accuracy, and must be distinguished from the much larger set of passenger alterations that are present in tumour DNA. Rigorous analysis and correct clinical interpretation of comprehensive genomic data is impossible without the assistance of computational algorithms to support clinical-grade data interpretation. Finally, haematologists must forge a cohesive framework whereby genomic information propels a new generation of evidence-based clinical trials.
Specific aims are:
a) To provide ABCs of genomics for clinicians
b) To provide information on recent advances in the understanding of the genome of haematological malignancies
c) To provide examples of the integration of somatic mutations into diagnosis and clinical decision-making in haematology.
The program will include:
– Plenary Sessions
– Simultaneous Meet the Experts Sessions
– Round Table Discussions
– Poster Presentations
PLEASE FIRST REGISTER FOR THE CONFERENCE BEFORE SUBMITTING AN ABSTRACT
Submit your abstract(s) on-line:
Please find below the abstract guidelines:
The following file types may be uploaded: HTML document (*.htm), HTML document (*.html), JPEG image (*.jpg), GIF image (*.gif), or PNG image (*.png).
Check that you do receive an acknowledgement of your submitted abstract. If not, contact Emilie Letertre.
IN ORDER TO BENEFIT FROM SPECIAL CONFERENCE RATES PLEASE BOOK YOUR HOTEL
ACCOMMODATION THROUGH THE HOTEL WEBSITE AFTER REGISTRATION:
Saggart, Co Dublin
Please insert the Promotional Code: ESH2016
Saggart, Co Dublin
The CityWest Hotel is located in Saggart just a 20 minute drive from Dublin International Airport.
It offers excellent conference facilities as well as onsite hotel accommodation.
The registration fee for the Training Course on WHO Classification: Towards Personalized Medicine in Haematology
600€ (fully trained)
300€ (in training: a proof will be requested to confirm your status)
This fee includes:
Your seat in the conference
The conference materials,
Welcome cocktail, luncheons and refreshments throughout the conference.
Your seat in the conference will be definitively reserved upon receipt of your fee.
Type of payment :
A) By Cheque :
ESH, Centre Hayem, Hôpital Saint Louis
1 Avenue Claude Vellefaux
75475 Paris Cedex 10
B) By Bank transfer :
NAME : ESH
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BIC code : BNPAFRPPPBU
C) By Credit card : VISA, MASTERCARD, AMEX
Cancellation policy of registration fee :
In case of cancellation, up until two months prior to the beginning of the meeting, your registration fee will be reimbursed in full (less bank charges).
If the cancellation is notified between 60 to 15 days prior to the beginning of the meeting, 50% of the registration fee will be reimbursed (less bank charges).
Cancellations notified 15 days before the meeting will not be reimbursed.
How to proceed :
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