ESH Video

ESH Workshop LEUKEMIC AND CANCER STEM CELLS

ESH Workshop LEUKEMIC AND CANCER STEM CELLS
April 29 - May 01, 2011 - Mandelieu La Napoule, France
Chairs :

Information

Objectives: The identification of cancer stem cells (CSC) in most cancers has led to the emergence of a new field in cancer research that is expected to provide insight into oncogenesis and hope for improved survival and cure. Evidence of CSC first arose in the field of hematology through the study of leukemia. Although a number of isolation techniques have been developed and a large body of data on leukemic stem cells (LSC) and Cancer Initiating Cells in solid tumors have accumulated, they have proved difficult to isolate and amplify. This
prompts hematologists to address the issue of the identification of novel markers with caution.

This ESH workshop aims to support the development of LSC networks in Europe. Since the first meeting in 2009, attended by more than 150 participants from over 26 countries, two networks have emerged from the group: the EHA Scientific Workgroup on Cancer and Leukemic Stem Cells and the EuroCSCTraining Network (7th People PCRD-Marie Curie) for young researchers.

Targeted audience: Researchers already in the field (or wishing to enter it), clinicians involved in novel targeted therapies, young researchers and biologists working in hematology or cancer research or hospital laboratories. Private companies involved in cancer stem cell identification or targeting.

Programme

Friday, April 29th, 2011
Session I - Signatures of “stem cellness”
14h00 - 14h30 Word of introductions C. Chomienne, D. Bonnet &
P. Valent
14h30 - 15h00 Stem cell pathways G. Sauvageau (Montreal)
15h00 - 15h30 Hypoxia signalling pathways in haematopoietic stem cell fate decisions K. Kranc (Glasgow)
15h30 - 16h00 Short Communications
15h30 - 15h45 The SCL/TAL1, LMO 1 and NOTCH 1 oncogenese are sufficient to transform thymocyte progenitors into leukemic stem cells T. Hoang (Montreal)
15h45 - 16h00 Self-renewal gene tracking to identify tumour initiating cells with metastatic potential A. Ladoux (Nice)
15h30 - 16h30 Coffee break and poster viewing (informal)
Session II - Cancer stem cell imaging and monitoring
16h30 - 17h00 In vivo imaging of normal and malignant haematopoietic stem progenitors cells C. Lo Celso (London)
17h00 - 17h30 In vivo 2 Photon  microscopy, a tool to investigate glioblastoma progression  at cellular resolution F. Debardieux (Marseille)
17h30 - 18h00 Whole animal imaging approaches in cancer and stem cell biology A. Kung (Boston)
18h00 - 18h30 Fiberoptic confocal imaging of femoral hematopoietic reconstitution and early development of myeloid leukemia D. Lewandowski (Paris)
18h45 - 20h00 Welcome cocktail and imaging tool demonstrations
Saturday, April 30th, 2011
Session III - Malignant stem cells in hematopoietic disease: Targets and targeting
08h30 - 10h30 Part I: Hematopoietic cancer stem cells: identification/ frequency and heterogeneity
08h30 - 09h00 Leukaemia initiating cells of fusion oncoproteins J.C. Mulloy (Cincinnati)
09h00 - 09h30 Clonal evolution of self-renewal in T-ALL D.M. Langenau (Boston)
09h30 - 10h00 The myeloma stem cell concept-revisited H.E. Johnsen (Arhus)
10h00 - 10h30 Short Communications
10h00 - 10h15 The role of CD123 in AML and CML: structure, biology and therapeutic opportunities A. Lopez (Adelaide)
10h15 - 10h30 Mitochondrial respiratory chain complex III generates reactive oxygen species initiating genomic instability in leukemia stem cells T. Skorski (Philadelphia)
10h30 - 11h00 Coffee break and poster viewing (Posters from nº1 to 12)
11h00 - 13h00 Part II: Solid tumor cancer stem cells: identification/ frequency and heterogeneity
11h00 - 11h30 Targeting malignant stem cells: Lessons from CML C. Eaves (Vancouver)
11h30 - 12h00 Malignant stem cells before and now R. De Maria (Rome)
12h00 - 12h30 Targeting mammary cancer stem cells G. Dontu  (London)
12h30 - 13h00 Short Communications
12h30 - 12h45 The role of adipose tissue derived stem cells in tumor initiation and progression R. Arlinghaus (Houston)
12h45 - 13h00 The miR 302 367 cluster drastically alters self-renewal and infiltration of Glioma-initiating cells through CXCR4 repression and the consequent disruption of SHH-GLI-NANOG network T. Virolle (Nice)
13h00 - 14h30 Lunch and poster viewing (Posters from nº13 to 25)
Session IV - Tools and procedures to study CSCs
14h30 - 16h00 Part I: Simultaneous workgroups sessions
- Workgroup on cell culture, purification and banking
- Workgroup on animal models and engraftment
- Workgroup on monitoring and tracking cancer stem cells
Workgroups Coordinated by Members of the EuroCSCT training Network, the Canceropôle Idf Stem Cell Network (F) and the EHA Scientific Workgroup on Leukemic Stem Cells.
Chairs and/or Speakers: Members of the EuroCSC Training Network FP7
D. Bonnet, P. Valent, S.E. Jacobsen, T. Enver, G. de Haan, J.J. Schuringa, M. Goodhardt, R.A. Padua, F. Louache,
H. Cheinweiss, R. Galli, M.Essers, F. Pfumio, V. Dangles-Marie, M.P. Junier
Industrial companies of EUrosCSCT, Becton-Dickinson, Miltenyi, StemCells- XenTech
16h00 - 16h30 Coffee break and poster viewing (informal)
16h30 - 18h30 Part II
16h30 - 17h15 Summary of the workgroups
17h15 - 17h40 Plateforms to study cancers stem cells R. De Maria (Rome)
17h40 - 18h00 Cell culture assays C. Eaves (Vancouver)
18h00 - 18h30 LSC Banks G. Sauvageau (Montreal)
Sunday, May 1st, 2011
Session V - Targeting Cancer Stem Cells
08h30 - 10h30

Part I: Targeting hematopoietic cancer stem cells

08h30 - 09h00 Targeting CML stem cells S. Li (Boston)
09h00 - 09h30 Targeting MLL leukaemia stem cells E. So (London)
10h00 - 10h30 Short Communications
10h00 - 10h15 Sequence of mutational events and clonal architecture in BCR-ABL positive acute lymphoblastic leukaemia M.J. Carnicer-Rodriguez (Sutton)
10h15 - 10h30 Leukemia initiating cells are frequent and detected in distinct clonal subsets in de novo resistant ALL M. Schmitz (Zurich)
10h30 - 11h00 Coffee break
11h00 - 12h30 Part II: Targeting solid cancer stem cells
11h00 - 11h30 Studying precancerous stem cells in mouse models of T-cell leukaemia M. McCormack (Parkville)
11h30 - 12h00 Targeting breast cancer stem cells via stable manipulation of cell state P. Gupta (Cambridge-USA)
12h00 - 12h30 Short Communications
12h00 - 12h15 AML engraftment in the NOD/SCID assay reflects intrinsic differences of the leukemic cells rather than incompability of the mouse microenvironement evidence by in vitro co-culture assays E. Griessinger (London)
12h15 - 12h30 Novel cell surface markers and targets expressed on CD34+/CD38- progenitor cells in patients with myeloid leukemias H. Hermann (Vienna)
12h30 - 12h45 Conclusion

Abstract submission

Symposia

Accommodation

Venue

Pullmann Mandelieu Royal Casino Hotel

605 Avenue du Général de Gaulle

06212 Mandelieu La Napoule

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