ESH Video

ESH International Conference MECHANISMS OF CELL DEATH AND DISEASE: ADVANCES IN THERAPEUTIC INTERVENTION AND DRUG DEVELOPMENT

ESH International Conference MECHANISMS OF CELL DEATH AND DISEASE: ADVANCES IN THERAPEUTIC INTERVENTION AND DRUG DEVELOPMENT
October 14 - October 18, 2010 - Cascais, Portugal
Chairs :

Information

Programme

Thursday, October 14, 2010
18h00-19h00 Opening presentation V. Dixit (San Francisco)
19h30

Welcome reception

20h00 Dinner
Friday, October 15, 2010
Session I - Death receptors - Chair: K.M.  Debatin (Ulm)
08h30-09h10 Apoptosis regulation in the CD95 system P. Krammer (Heidelberg)
09h10-09h50 Role of CD95 in T-cell silencing K.M. Debatin (Ulm)
09h50-10h30 Signalling within the TNF family D. Wallach (Rehovot)
10h30-11h00 Coffee break
11h00-11h40 The TRAIL-caspase connection G. Cohen (Leicester)
11h40-12h20 Understanding TRAIL sensitivity H. Walczak (London)
12h20-13h00 Death ligands designed to kill K. Pfizenmeier (Stuttgart)
13h00-14h30 Lunch
Session II: Death Receptors - Chair G. Cohen (Leicester)
14h30-15h10 Targeting pro-apoptotic receptors in cancer.
The therapeutic potential of APO2L/TRAIL

P. Holland (Seattle)

15h10-15h50

Inducing apoptosis with TRAIL receptor antibodies

R. Humphreys (Rockville)
15h50-16h30 Therapeutic potential of APG101 (CD95Fc) in graft versus host disease and tissue damage H. Fricke (Heidelberg)
16h30-17h00 Coffee Break
17h00-17h40 ApoFLIP: a novel bioactive peptide that restarts the apoptotic machinery in cancer cells R. Khosravi-Far (Boston)
17h40-18h20 Round table:
Death receptor signalling, sensitivity and resistance in the clinical setting
20h00 Dinner
21h15-22h15 Poster Session (1)

Saturday, October 16, 2010

Session III:  IAP Inhibitors - Chair: T. McDonnel (Houston)
08h30-09h10 Targeting IAPs for theraupeutic intervention D. Vucic (San Francisco)
09h10-09h50 Smac-mimetics/IAPs inhibitors as proapoptotic agents for cancer therapy E. Mastrangelo (Milano)
09h50 - 10h30 IAPS as targets for cancer therapy S. Fulda (Ulm)
10h30-11h00 Coffee Break
11h00-11h40 IAPs and beyond

J. Silke (Victoria)

11h40-12h20

XIAP inhibition in apoptosis

J. Gillard (Montreal)
12h20-13h00 Theraupetic targeting of IAPs D. Porter (Cambridge-US)
13h00-14h30 Lunch

14h30-19h00

Free time and visit to Cascais
20h00 Dinner
21h15-22h15 Poster Session (2)

Sunday, October 17, 2010

Session IV: Biomakers - Chair: T. McDonnel (Houston)
09h00-09h40 Biomarker - based approaches of targeted therapy for lung cancer elimination: the BATTLE clinical trials I Wistuba (Houston)
09h40-10h20

Assessments of biologic pathways as predictors of response to therapy in breast cancer

W. Fraser Symmans (Houston)
10h20-10h50 Coffee Break
10h50-11h30 Biomarkers for mechanism-driven pro-apoptotic drugs C. Dive (Manchester)
11h30-12h10

Biomarker roundtable
C. Dive, T.J. McDonnell, W. Fraser-Symmans, I. Wistuba

12h10-13h30 Lunch
Session V: Updates and New Targets - Chair: V. Dixit (San Francisco)
13h30-14h10 Ubiquitin and the control of cell death P. Meier (London)
14h10-14h50 Structural determinants of polyubiquitin chain recognition D. Komander (Cambridge, UK)
14h50-15h30

Ubiquitin specific proteases as drug targets

F. Colland (Paris)
15h30-16h00 Coffee break
Chair: J.A. Hickman (Croissy sur Seine)
16h00-16h40

Discovery of new inhibitors of the Bcl-2family of proteins

G. Lessene (Melbourne)
16h40-17h20 Navitoclax (ABT-263), a clinical update G. Gordon (Abbott Park, Chicago)
17h20-18h00 Tumour suppressor and tumour maintenance genes S. Lowe (Cold Spring Harbor)
20h00 Conference Dinner

Monday, October, 18, 2010

BUS Departure

Abstract submission

Symposia

Accommodation

Venue

Hotel Quinta da Marinha Resort

Quinta da Marinha

2750-715 Cascais

Corporate partners

Scholarship

Workshop

Registration