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ESH-EHA Scientific Workshop T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL) MEETS NORMAL T-CELL DEVELOPMENT

ESH-EHA Scientific Workshop T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL) MEETS NORMAL T-CELL DEVELOPMENT
May 07 - May 09, 2010 - Mandelieu La Napoule, France
Chairs :

Information

Programme

Friday, May 7, 2010

14h00 - 14h10 Welcome to the participants
14h10 - 15h30 Introduction key note conferences:
14h10 - 14h50 Normal T-cell development

H. von Boehmer (Boston)
14h50 - 15h30 Acute T-cell lymphoblastic leukemia
A.T. Look (Boston)

 

Session 1: Normal and leukemic lymphoid development in the thymus (1)
15h30 - 16h00 TBA M. L. Toribio (Madrid)
16h00 - 16h30 Coffee break
16h30 - 17h00 Controlling Hematopoiesis one Ubiquitin Ligase at a Time I. Aifantis (New York)
17h00 - 17h30 Wnt signaling in normal and malignant T cell development F.J. Staal (Leiden)
17h30 - 18h00 Novel insights into Notch signaling events during normal human T cell development T. Taghon (Gent)
18h00 - 18h15 Selected short communication U. Koch (Lausanne)
18h15 - 18h30 Selected short communication C.J. Guidos (Toronto)
18h30 - 19h30 Poster viewing
20h00 Dinner

Saturday, May 8, 2010

Session 2: Signaling pathways in normal and leukemic T cells
08h30 - 09h00 Critical functions for Notch dimerization in T cell development and transformation W. Pear (Philadelphia)
09h00 - 09h30 Tyrosine kinases and phosphatases in the development of T-ALL J. Cools (Leuven)
09h30 - 10h00 The calcinreurin/NFAT signaling module in lymphoïd malignancies J. Ghysdael (Orsay)
10h00 - 10h15 Selected short communication I. Screpanti (Rome)
10h15 - 10h30 Selected short communication B. Canque (Paris)
10h30 - 11h00 Coffee break
Session 3: Genetics, epigenomics, and expression analysis in T-cell acute lymphoblastic leukemia
11h00 - 11h30 New Genetic subgroups in T-ALL J.P. Meijerink (Rotterdam)
11h30 - 12h00 Genetic/Biologic pathways in T-ALL J. Soulier (Paris)
12h00 - 12h30 PHF6 mutations in T-cell acute lymphoblastic leukemia P. Van Vlierberghe (Gent and NY)
12h30 - 12h45 Selected short communication H.G. Wendel (New York)
12h45 - 13h00 Selected short communication J.S Blackburn (Boston)
13h00 Lunch
Session 4: Normal and leukemic lymphoid development in the thymus (2)
14h30 - 15h00 TBA F. Radtke (Lausanne)
15h00 - 15h30 From modeling human T cell development in vitro to in vivo applications of immune-reconstitution J.C. Zúñiga-Pflücker (Toronto)
15h30 - 16h00 Exploring NOTCH, TAL1 and ERK pathways in human normal and leukemic T cell development F. Pflumio (Fontenay-aux-Roses)
16h00 - 16h30 Lmo2 induces precancerous stem cells in the thymus: T-ALL meets stem cell Biology M. McCormack (Melbourne)
16h30 - 17h00 Coffee break
17h00 - 19h00 Poster session
20h00 Dinner

Sunday, May 9, 2010

Session 5: T-ALL therapy; molecular targets, prognostic markers
08h30 - 09h00 TBA A.A. Ferrando (New York)
09h00 - 09h30 T-All signals: translating posttranslational alterations into therapy? J.T. Barata (Lisbon)
09h30 - 09h45 Defining a Burkitt-like model of MYC-mediated oncogenesis in T-ALL B. Nadel (Marseille-Luminy)
10h00 - 10h15 Selected short communication A. Gutierrez (Boston)
10h15 - 10h30 Selected short communication L. Zuurbier (Rotterdam)
10h30 - 11h00 Coffee break
11h00 - 11h30 T-ALL and T-LBL and their potential for hypothesis generating studies E.A. Macintyre (Paris)
11h30 - 12h00 Novel modes of Notch1 activation in T-ALL: implications for targeted therapy J. Aster (Boston)
12h00 - 12h15 Selected short communication P. Kastner (Ilkirch)
12h15 - 12h30 Selected short communication M.L. Hermiston (San Francisco)
12h30 - 12h45 Selected short communication N.S. Trede (Salt Lake City)
12h45 - 13h00 Selected short communication M.A. Kelliher (Worcester)
13h00 Conference closure
13h00

Lunch


Abstract submission

Symposia

Accommodation

Venue

Pulllman Mandelieu Royal Casino Hotel

605 Avenue du Général de Gaulle

06212 Mandelieu La Napoule

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Workshop

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