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Thursday, October 16 |
| 12:00 |
Registration |
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| Session 1 |
Cord blood transplant: banking, organization, regulatory issues
Chair: P. Wernet, P. Rubinstein |
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| 14.00-14.15 |
Netcord organization |
J. Garcia (Barcelona) |
| 14.15-14.30 |
Challenges in the international exchange of CBUs |
M. Boo (Minneapolis) |
| 14.30-14.45 |
Biological resource center |
P. Rebulla (Milan) |
| 14.45-15.00 |
Report from Japan and Asia |
S. Kato (Isehara) |
| 15.00-15.15 |
Latin America |
E. Calderon (Mexico City) |
| 15.15-15.30 |
London cord blood bank |
C. Navarrete (London) |
| 15.30 - 16.00 |
Coffee-Break |
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| 16.00-16.30 |
Sibling cord blood banking |
B. Lubin (Oakland) |
| 16.30-17.00 |
The unrealized potential of umbilical cord blood units for unrelated donor hematopoietic cell transplantation. |
L. Petz (Arcadia) |
| 17.00-18.00 |
Debate: Is there a place for autologous cord blood banking? |
L. Petz (Arcadia)
G. Garrido (Madrid)
Y. Beguin (Liège) |
| 19.00 |
Opening Ceremony Celebration Cord Blood Transplant History
Guest of Honour: Emmanuelle PRADA BORDENAVE Director General of the French National Biomedical Agency (directrice générale de l'Agence de la biomédecine)
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Special Guests:
A. Auerbach (New York)
M. Benbunan (Paris)
H. Broxmeyer (Indianapolis)
M. Contreras (London)
E. Gluckman (Paris)
J. Kurtzberg (Durham),
P. Rubinstein (New York)
G. Sirchia (Milan)
J.J. Van Rood (Leiden)
J. Wagner (Minneapolis)
P. Wernet (Dusseldorf)
and Patients |
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Friday, October 17 |
| Session 2 |
Stem cells from cord blood – Chair: W. Fibbe, P. Simmons |
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| 9.00-9.30 |
Cord blood-derived very small embryonic like (VSEL) stem cells |
M. Ratajczak (Louisville) |
| 9.30-10.00 |
Biology of cord blood stem cells |
P. Simmons (Houston) |
| 10.00-10.30 |
Functional characterization of stem cell subpopulations in cord blood |
G. Kögler (Düsseldorf) |
| 10.30-11.00 |
Coffee-Break |
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| 11.00-11.30 |
Embryonic like cells from umbilical cord blood |
C. McGuckin (Newcastle) |
| 11.30-12.00 |
The umbilical cord as a stem cell source: cells derived from Wharton's Jelly |
M.L. Weiss (Manhatten) |
| 12.00-12.30 |
Notch signalling in haematopoietic stem cell differentiation: implications for cord blood transplantation |
I. Bernstein (Seattle) |
| 12.30-13.00 |
Mesenchymal stem cells: Role in cord blood transplantation |
W. Fibbe (Leiden) |
| 13.00-14.00 |
Buffet lunch and poster viewing |
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| Session 3 |
The role of the hematopoietic microenvironment on hematopoietic stem cell function
Chair: H.E.Broxmeyer, G. Kögler |
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| 14.00-14.30 |
Re-defining human circulating endothelial progenitor cells |
M.C. Yoder (Indianapolis) |
| 14.30-15.00 |
Early foetal MSC and maternal and foetal tissue repair |
N.M. Fisk (Brisbane) |
| 15.00-15.30 |
USSC from Cord Blood as Neuronal Progenitors and their Strong Tropism for Neuronal Injury Areas |
P. Wernet (Düsseldorf) |
| 15.30-16.00 |
Cord blood to treat neurological diseases |
J. Kurtzberg (Durham) |
| 16.00-16.30 |
Coffee-break and poster viewing |
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| 16.30-17.00 |
Isolation and characterization of cells from human term placenta |
O. Parolini (Brescia) |
| 17.00-17.30 |
Stem cells and microenvironment |
J.A. Cancelas (Cincinnati) |
| 17.30-18.00 |
Resetting the immune-clock: Stemcellness vs.diversity |
D. Charron (Paris) |
| 18.00-18.30 |
Discussion |
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Saturday, October 18 |
| Session 4 |
Immunological properties – Chair: D. Charron, J.J. Van Rood |
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| 8.00-8.30 |
Umbilical cord blood-derived T cells expressing chimeric antigen receptor to target B-cell malignancies |
P. Dotti (Houston) |
| 8.30-9.00 |
Immune properties of cord blood |
F. Falkengurg (Leiden) |
| 9.00-9.30 |
Virus specific cord blood T cells for clinical use |
C. Bollard (Houston) |
| 9.30-10.00 |
Natural killer cells in cord blood and stem cell transplantation |
R. Champlin (Houston) |
| 10.00-10.30 |
Coffee-Break |
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| Session 5 |
Role of HLA in cord blood transplant – Chair: J. Wagner, V. Rocha |
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| 10.30-11.00 |
Influence of KIR mismatching in the outcome of cord blood transplant |
R. Willemze (Leiden) |
| 11.00-11.30 |
Role of HLA and cell dose in cord blood transplant |
P. Rubinstein (New York) |
| 11.30-12.30 |
Panel discussion on donor choice |
J. Wagner (Minneapolis)
P. Rubinstein (New York)
E. Gluckman (Paris)
M. Eapen (Milwaukee) |
| 12.30 - 13.30 |
Lunch |
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| Session 6 |
Clinical results in adults - R. Champlin, J. Barker |
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| 13.30-14.00 |
Cord Blood or non T-cell depleted haploidentical transplant for patients with haematological malignancies |
A. Picardi (Rome) |
| 14.00-14.30 |
Acute leukaemia |
V. Rocha (Paris) |
| 14.30-15.00 |
Double cord blood transplant |
J. Wagner (Minneapolis) |
| Session 7 |
Cord blood transplant in children - Chair: J. Kurtzberg, F. Locatelli |
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| 15.00-15.30 |
Hurler |
J. Boelens (Utrecht) |
| 15.30-16.00 |
Leukaemia |
F. Locatelli (Pavia) |
| 16.00-16.30 |
Haemoglobinopathies |
M. Walters (Oakland) |
| 16.30-17.00 |
Coffee-Break |
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| 17.00-18.30 |
Selected abstracts and poster presentation - E.J. Shpall, E. Gluckman, J. Garcia |
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| 1 |
Significant expansion of cord blood natural killer cells and decrease in T-cells following ex-vivo stimulation with genetic reengineering K652 cells overexpressing membrane bound il-15 and 4-1BBL (K562-mbIL 15-41BBL) |
M. Cairo (New York) |
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Umbilical cord tissue derived mesenchymal stromal cells are immunosuppressive and require monocytes for optimal inhibition of proliferation |
A. Cutler (London) |
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Classification of human unrestricted somatic stem cells by adipogenic differentiation and DLK1 expression |
S. M. Kluth (Düsseldorf) |
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Mesenchymal stem cells from umbilical cord blood, bone marrow and adipocyte tissue as sources of chondrocytes: they could be used to repair cartilage? |
A. Luzo (São Paulo) |
| 5 |
Endothelial progenitor cells from umbilical cord blood for tissue repair |
S. Watt (Oxford) |
| 6 |
Integration of functional bacterial artificial chromosomes into human cord blood derived multipotent stem cells |
F. Zaibak (Melbourne) |
| 7 |
Dopes ethnicity affect cell dose in cord blood donation ? |
F. Regan (London) |
| 8 |
Reduced intensity (RIC) vs myeloablative conditioning (MAC) prior to cord blood transplantation (CBT) in pediatric recipients results in similar time to engraftment and donn chimerism but a significantly decreades probability of grade II-IV AGVHD and dat 100 mortality |
M. Cairo (New York) |
| 9 |
Reduced intensity conditioning umbilical cord blood transplantation (RIC-UCBT) in adults: Age, disease status and infectious complications are important risk factors for outcome |
S. Furst (Marseille) |
| 10 |
Influence of myeloblative conditioning regimens on outcomes after single unrelated cord blood transplantation for adults with leukaemia:and analysis on behalf of Eurocord EBMT Netcord |
S. K. Nabham (Paris) |
| 11 |
Plasmacytoid CD 123+dendritic cell recovery is an independent predictor of survival after unrelated cord blood transplant (UCBT) |
P. Szabolcs (Durham) |
| 12 |
Single donor 4/6 matched banked unrelated cord blood is an effective graft source for children undergoing myloablative transplantation for malignant and nonmalignat disorders: single center analysis of 318 patients |
V. K. Prasad (Durham) |
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Sunday, October 19 |
| Session 8 |
Graft facilitation-Homing – Chair: F. Frassoni, T. Lapidot |
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| 8.30-9.00 |
Mechanistic insights into engraftment |
H.E. Broxmeyer (Indianapolis) |
| 9.00-9.30 |
Dynamic interations between the nervous and immune systems with microenvironment regulate hematopoietic stem cells |
T. Lapidot (Rehovot) |
| 9.30-10.00 |
Stem cells and their niche: a leverage point for therapy |
D. Scadden (Boston) |
| 10.00-10.30 |
Methods for promoting engraftment |
E.J. Shpall (Houston) |
| 10.30-11.00 |
Coffee-Break |
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| Session 9 |
New protocols for cord blood transplant - Chair: E. Gluckman, M. Eapen |
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| 11.00-11.30 |
Lymphoma |
C. A. Rodrigues (São Paulo) |
| 11.30-12.00 |
Reduced intensity conditioning |
J. Barker (New York) |
| 12.00-12.30 |
Direct intra-bone (IBM) transplant of cord blood cells |
F. Frassoni (Genoa) |
| 12.30-13.00 |
Discussion |
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