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| Thursday, October 30 |
| 17:00-18:00 |
Keynote lecture |
S. Cory (Melbourne) |
| 19:30 |
Welcome cocktail |
|
| 20:00 |
Dinner |
|
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| Friday, October 31 |
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BCL-2 family members past and present challenges |
|
| 08:30-09:10 |
Role of microRNAs in apoptosis and disease |
C. Croce (Columbus) |
| 09:10-09:50 |
Roles of Bcl-2 in apoptosis and necrosis |
Y. Tsujimoto (Osaka) |
| 10:00-10:30 |
Coffee break and poster viewing |
|
| 10:30-11:10 |
The role of pro-survival Bcl-2 family members in tumour
development and sustained tumour growth |
A. Strasser (Melbourne) |
| 11:10-11:50 |
Understanding, detecting and exploiting dependence on BCL-2 |
A. Letai (Boston) |
| 11:50-12:30 |
Short communications |
|
| 12:30-14:00 |
Lunch |
|
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ER and mitochondrial roles |
|
| 14:00-14:40 |
Mitochondria fission, fusion and apoptosis |
R. Youle (Bethesda) |
| 14:40-15:20 |
Mechanisms of bax activation |
J.-C. Martinou (Geneva) |
| 15:20-15:40 |
Coffee break and poster viewing |
|
| 15:40-16:20 |
Bcl-2 and Bcl-XL: Versatile regulators of calcium signaling |
C. Distelhorst (Cleveland) |
| 16:20-17:00 |
Buridan's ass and the membrane activity of Bcl-2 proteins |
R.B. Hill (Baltimore) |
| 17:00-18:30 |
Manned poster session 1 |
|
| 20:00 |
Dinner |
|
| |
| Saturday, November 1 |
| 08:30-09:10 |
Activation and activity of the BH3-only protein Bim |
G. Häcker (Munich) |
| 09:10-09:50 |
Cancer cell dependence on anti-apoptotic Bcl-2 family members |
P. Juin (Nantes) |
| 09:50-10:30 |
The Bcl-2 family clan: Who is talking to whom? |
C. Borner (Freiburg) |
| 10:30-11:00 |
Coffee break and poster viewing |
|
| 11:00-11:40 |
Title Pending |
S. May (Gainesville) |
| 11:40-12:20 |
Embedded together: The life and death consequences of Bcl-2 protein interactions with membranes |
D. Andrews (Ontario) |
| 12:20-13:00 |
Mapping genetic paths to tumourigenesis |
M. Hardwick (Baltimore) |
| |
Lunch and free afternoon in Lisbon |
|
| 19:00-20:00 |
Pre-dinner talk: Evading cell death and senescence during leukogenesis |
S. Lowe (New York) |
| 20:00 |
Dinner |
|
| |
| Sunday, November 2 |
| |
MCL-1 and non-death roles for Bcl-2 |
|
| 08:30-09:10 |
Regulating cell survival by controlling protein stability |
D. Huang (Melbourne) |
| 09:10-09:50 |
Connecting multiple cell death pathways by mitochondrial proteins |
X. Wang (Dallas) |
| 09:50-10:30 |
Mechanisms of MCL1 regulation - signs of a therapeutic target? |
R. Craig (Hanover-USA) |
| 10:30-11:00 |
Coffee break and poster viewing |
|
| 11:00-11:40 |
Mitochondrial death channel in neuronal ischemia |
L. Jonas (New Haven) |
| 11:40-12:20 |
BCL-2 proteins in neuroprotection and plasticity |
P. Nicotera (Leiscester) |
| 12:20-13:00 |
Short communications |
|
| 13:00-14:00 |
Lunch |
|
| |
Structure-Function and drug discovery |
|
| 14:00-14:40 |
Structure and functiom of myxoma virus and vaccinia virus Bcl-2 homologues |
P. Colman (Melbourne) |
| 14:40-15:20 |
Title Pending |
Y. Shi (Princeton) |
| 15:20-15:40 |
Structural studies of BH3 domains to Bcl-2 family of proteins |
R. Hubbard (York) |
| 15:40-16:00 |
Coffee break and poster viewing
|
|
| 16:00-16:40 |
Challenges in developing SMAC or BAD mimetics as cancer therapeutics |
S. Fawell (Cambridge-USA) |
| 16:40-17:20 |
IAP antagonists and TNF induced apoptosis |
V. Dixit (San Francisco) |
| 17:30-18:30 |
Manned poster session |
|
| 18:30-19:30 |
Pre-dinner talk: Apoptosis inhibitors from woe to go |
D. Vaux (Victoria) |
| 20:00 |
Dinner |
|
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| Monday, November 3 |
| |
Metabolism / autophagy / hypoxia |
|
| 09:00-09:40 |
Role of autophagy in cancer |
E. White (Piscataway) |
| 09:40-10:20 |
Title Pending |
B. Levine (Dallas) |
| 10:20-11:00 |
Coffee break |
|
| 11:00-11:40 |
Self-eating and self-killing: desperate reactions of cancer cells |
G. Kroemer (Villejuif) |
| 11:40-12:20 |
BNIP3 and BNIP3L in hypoxia induced autophagy |
J. Pouyssegur (Nice) |
| 12:20-13:00 |
Short communications |
|
| 13:00-14:00 |
Lunch |
|
| |
Clinical results |
|
| 14:00-14:40 |
Germinal centre cell lymphoma? Room for novel therapy |
A. Lister (London) |
| 14:40-15:20 |
Targeting prosurvival Bcl-2 family proteins with ABT-263 |
S. Elmore (Abbott Park) |
| 15:20-16:00 |
Clinical experience with BcL-2 inhibitors |
Pending |
| 16:00-16:30 |
Coffee break and poster viewing |
|
| 16:30-17:10 |
Pharmacological biomarkers in early clinical trials of apoptosis targeted drugs |
C. Dive (Manchester) |
| 17:10-18:00 |
Title Pending |
J. Reed (La Jolla) |
| 18:00 |
Closing Address: Title Pending |
J. Adams (Melbourne) |
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Cocktails | Dinner | Party |
|
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| Tuesday, November 4 |
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Departure |
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